Detalhe da pesquisa
1.
The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
Mol Cell
; 69(1): 87-99.e7, 2018 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29249655
2.
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.
Nature
; 539(7628): 304-308, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27783593
3.
Germline mutations: many roles in leukemogenesis.
Curr Opin Hematol
; 27(4): 288-293, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32487806
4.
The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
J Pathol
; 247(1): 135-146, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30376595
5.
Targeting HIF-1α in combination with PPARα activation and postnatal factors promotes the metabolic maturation of human induced pluripotent stem cell-derived cardiomyocytes.
J Mol Cell Cardiol
; 132: 120-135, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31082397
6.
Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
Proc Natl Acad Sci U S A
; 113(4): 984-9, 2016 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755576
7.
Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism.
Blood
; 125(10): 1562-5, 2015 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25593337
8.
Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis.
Curr Opin Hematol
; 23(4): 339-45, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27071022
9.
Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells.
J Biol Chem
; 289(1): 251-63, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24265312
10.
Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.
J Biol Chem
; 288(36): 25727-25738, 2013 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23884424
11.
CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment.
Blood
; 130(12): 1471-1474, 2017 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28751523
12.
Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts.
Mol Cell Biochem
; 392(1-2): 31-7, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24623267
13.
Metabolic plasticity and hematopoietic stem cell biology.
Curr Opin Hematol
; 20(4): 289-94, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23615055
14.
Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity.
Sci Adv
; 9(49): eadf9522, 2023 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38055827
15.
Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice.
Elife
; 122023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37672386
16.
AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling.
Stem Cell Res Ther
; 14(1): 322, 2023 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37941041
17.
A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
Blood
; 116(18): 3611-21, 2010 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20651068
18.
Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
Sci Rep
; 12(1): 21832, 2022 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36528691
19.
JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1ß.
Blood Adv
; 6(1): 200-206, 2022 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34555844
20.
Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.
Cell Chem Biol
; 29(7): 1200-1208.e6, 2022 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35429459